x-pur remin box
Nano Medical Hydroxyapatite Toothpaste

The #1 fluoride free toothpaste indicated to reduce caries

Professionals Consumers

Mechanism of action

The main substance of our teeth is hydroxyapatite (97 % of enamel and 70 % of dentin), a calcium phosphate compound. This ingredient is safe and highly biocompatible. Nano medical hydroxyapatite (<mHAP>) particles penetrate below the surface of the enamel, providing replacement calcium and phosphate ions to areas from which minerals have dissolved, thereby remineralizing the demineralized enamel and restoring its integrity and translucent gloss.

100% natural: GMO, gluten and sugar free

Environmentally friendly
X-PUR Remin does not contain plastic particles which are a significant source of ocean and beach plastic pollution.

Free of harsh foaming agents such as sodium lauryl sulfate (SLS) or triclosan
SLS is a foaming agent used in dish soaps, liquid laundry detergents, toilet-bowl cleaners, shampoos and in the majority of all toothpastes. It is an irritating substance and may be responsible for oral ulcerations. Triclosan is an antibacterial agent whose use has become widespread in toothpastes, cosmetics and plastics. It is suspected to interfere with hormone function and can irritate the skin and the eyes. The American Medical Association recommends avoiding triclosan entirely.
Improves teeth whiteness and gloss
Nano medical hydroxyapatite is not an abrasive or whitening agent in the sense of scrubbing or bleaching the teeth. In fact, by providing minerals to repair surface crevices, it restores, smooths and gives translucency to the enamel, improving its gloss and true color.

Lightly flavoured
The mild mint flavour leaves the mouth feeling refreshed without an unpleasant or irritating aftertaste.

Low abrasivity
RDA level of 60

Neutral pH 7.51

Sweetened with 10 % xylitol, for a great taste
Contrary to the majority of toothpastes, X-PUR Remin doesn’t contain acesulfame potassium, an artificial sweetener that may be associated with several health problems.

Ingredients

Medicinal Ingredient
10 % Nano Medical Hydroxyapatite
10% Xylitol

Non-Medicinal Ingredients
Water, macrogol 400, zeolite, polyvinylpyrrolidone, glycyrrthetinc acid, cetylpyridinium chloride, glycerin, xylitol, dimethylsilyl silicic anhydride, castor oil, sodium lauroyl glutamate, carragenan, ethanol, carboxymethylcellulose sodium, titanium dioxide, flavor.

Flavor

Mild mint

NPN

80061255

Indication

  • Helps to remineralize tooth enamel (which helps against xerostomia)
  • Helps to reduce pain caused by tooth sensitivity
  • Helps to reduce caries

Clinical uses

  • Geriatrics
  • High risk caries
  • Oncology treatment
  • Pediatrics
  • Periodontitis
  • Whitening
  • Xerostomia

Directions for use

Adults and children
At least 2 times per day
  1. Brush with a film of toothpaste. Expectorate
  2. For optimal results, do not eat, drink or rinse for 30 minutes

Medicinal Ingredients

REMINERALIZATION AND REPARATION OF TOOTH SURFACES

  • Causes remineralization comparable to a fluoride toothpaste and inhibits caries development, thus suggesting that a nano medical hydroxyapatite toothpaste can be an effective alternative to fluoride toothpastes
  • Remineralizes subsurface demineralized areas of tooth enamel
  • Remineralizes tooth enamel more effectively than saliva and just as effectively as fluoride compounds. Note: fluoride promotes remineralization by saliva, where as nano medical hydroxyapatite itself remineralizes the teeth
  • Fills and repairs minute surface defects on tooth enamel, restoring enamel to its original smoothness
  • Adheres to and helps remove bacteria and biofilm, thereby protecting against tooth decay
  • Removes white spots and incipient caries and restores enamel almost to its original form
  • Protects against biofilm attachment and stains by reducing the crevices that harbor them

ANTIMICROBIAL PROPERTIES

  • Absorbs periodontal and opportunistic pathogens such as p.gingivalis and candida, helping reduce the risk of oral soft tissue infection
  • Shows superior bacterial absorption compared with other forms of hydroxyapatite
  • Shows strong selectivity for cariogenic streptococcus mutans

TOOTH SENSITIVITY TREATMENT

Coats and fills exposed dentin and dentinal tubules, protecting against dentinal hypersensitivity.

TOOTH WHITENESS AND GLOSS

Improves tooth whiteness and gloss, which can be correlated with an increase in surface minerals and smoothness.

HISTORY OF MEDICAL HYDROXYAPATITE TOOTHPASTES

1970 1970:First synthetic form of hydroxyapatite created by NASA to help restore teeth and bone loss by astronauts following gravity-free environment missions.
1978:Sangi Co., Ltd. acquires the patent from NASA and conceives the idea of an enamel-restorative toothpaste using the same substance as the tooth structure (hydroxyapatite).
1980 1980: Sangi launches the world’s first enamel-restorative toothpaste in Japan.

1985, studies from: Tokyo Medical and Dental University (1 year / 1,026 children)
Asahi University (3 years / 181 children)

Results: Nano medical hydroxyapatite significantly lowered the incidence of new caries in previously and newly erupted teeth. In the 3-year study, the reduction was as high as 36 % to 56 %.
1920 1993: The Japanese government approves Sangi’s proprietary medical hydroxyapatite as an active anti-caries agent.
2000 2003: Sangi increases the enamel-restorative capabilities of medical hydroxyapatite by reducing its nanoparticles from 100 to 50 nanometers (1 nanometer = 1 million of a millimeter), making it more effective at penetrating below the surface of the enamel.

2013: 100 million medical hydroxyapatite toothpastes are sold by Sangi over the last 35 years. Nano medical hydroxyapatite is now the gold standard in Japan to fight cavities against caries.

2015: X-PUR Remin is granted the Health Canada indication of a fluoride free toothpaste that helps reduce caries.

Testimonials

For about two years I had been dealing with a tooth in which a large filling that had fallen out. I was shocked and surprised when Remin toothpaste sealed that tooth completely (with no bacterial contamination). This is after I decided that I would use Remin 5 times per day. My teeth are also becoming super white too.

- Brian J., a patient

Love love love this toothpaste. I was looking for a fluoride-free remineralizing option and this was recommended to me by a hygienist. It has taken away the little bit of sensitivity I had and made them shinier-- they look overall healthier.

- Silvia, a patient

My teeth were becoming critically sensitive and I started using this product and it is definitely fixing the problem!

- Cliff, a patient

Featured Publications

Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice

Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice

Xerostomia: Are You Ready for the Silver Tsunami?

Xerostomia: Are You Ready for the Silver Tsunami?

Enamel surface remineralization: Using synthetic nanohydroxyapatite

Enamel surface remineralization: Using synthetic nanohydroxyapatite

1964 Effect of hydroxyapatite toothpaste on vital tooth color

1964 Effect of hydroxyapatite toothpaste on vital tooth color

Dental Maintenance of the Medically Compromised Patient

Dental Maintenance of the Medically Compromised Patient

all x-pur products

References

  1. AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [LINK]
  2. AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [LINK]
  3. KANI et al, The Effect of Apatite-containing Dentifrices on Artificial Caries Lesions, The Journal of Dental Health 38, 364-366, 1988. [LINK]
  4. AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [LINK]
  5. NISHIMURA et al, Demineralized Enamel Surface Microstructure after Brushing Using Toothpaste Containing Medical Hydroxyapatite under FE-SEM Observation, The Journal of Japanese Stomatological Society, 48(3), 199-210, 1999. [LINK]
  6. ARAKAWA et al, Reduction of Oral Mutans streptococci by Small-Crystals, 82nd General Session & Exhibition of the IADR, March 10-13, 2004. [LINK]
  7. ARAKAWA et al, Reduction of Oral Mutans Streptococci by Small Crystal Hydroxyapatite, The Journal of Dental Research, Vol. 83, 2036, Honolulu Abstracts, 2004. [LINK]
  8. AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [LINK]
  9. ARAKAWA et al, Reduction of Oral Mutans Streptococci by Small Crystal Hydroxyapatite, Journal of Dental Research Vol. 81, A200-1478, San Diego Abstracts, 2002. [LINK]
  10. ARAKAWA et al, Adsorption Effect of Hydroxyapatite to Oral Streptococci, Journal of Dental Research, Vol. 83, 2036, Honolulu Abstracts, 2004. [LINK]
  11. KONDO et al, Study of Streptococcus Mutans Adherence to Hydroxyapatite, The Journal of Dental Health, Vol. 49, 614-615, 1999. [Article in Japanese]
  12. ARAKAWA et al, Reduction of Oral Mutans Streptococci by Small Crystal Hydroxyapatite, The Journal of Dental Research, Vol. 83, 2036, Honolulu Abstracts, 2004. [LINK]
  13. OHTA et al, Occlusion of Dentinal Tubules by Nano-Hydroxyapatite, The Journal of Dental Research, Vol 86, Special Issue A (New Orleans Abstract), 2007. [LINK]
  14. GUO et al, Effect of Hydroxyapatite Toothpaste on Vital Tooth Color, The Journal of Dental Research, Vol. 81, 1964, San Diego Abstracts, 2002. [LINK]