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Liquid Non-Injectable Topical Anesthetic

Profound, quick onset, long-lasting and cost-effective anesthesia


Mechanism of action

The combination of benzocaine (short duration for a quick onset in 30 seconds), tetracaine hydrochloride (slow onset for an extended duration of 30 to 60 minutes) and butamben (intermediate action bridge) acts by reversibly blocking nerve conduction. The speed and duration of action are determined by the ability of these agents to be absorbed by the mucous membrane and nerve sheath and then diffuse out.


Production of anesthesia of all accessible mucous membranes except the eyes. Ideal for these situations :

  • Implants uncovery
  • Laser dentistry
  • Periodontal treatment
  • Pre-probing procedures
  • Pre-scaling and root planing procedures
  • Retraction cord placement
  • Rubber dam placement
  • Topical anesthetic for pre-injection
  • X-ray radiography


  • 24g bottle = 60 full mouths or 240 quadrant applications
  • Cost-efficient : approximately $2.04 per quadrant
  • Enhances patient comfort and co-operation
  • Improved patient chairside experience
  • Long lasting : 30 to 60 minutes
  • Luer-lock system allows to extrude only the necessary quantity
  • Methemoglobinemia: no case has ever been reported
  • Pleasant banana taste
  • Quick onset : 30 to 60 seconds
  • Thin and flexible applicator for sub-gingival application

Active Ingredients

  • 14% Benzocaine
  • 2% Butamben
  • 2% Tetracaine Hydrochloride



Kit includes

  • 24g Cetacaine liquid bottle
  • Luer-lock dispenser cap
  • 100 graduated 0.4ml dispensing syringes
  • 100 microcapillary dispensing tips

Directions for use

  1. Remove and discard the shipping cap, discard and replace with luer-lock dispensing cap. Once dispensing cap is in place, it should not be removed
  2. Remove the small cap from the luer-lock port. Retain for replacement after use
  3. Lock a delivery syringe onto the port
  4. Invert the bottle and slowly draw liquid (0.4ml maximum) into the syringe. If air is drawn into syringe, push the liquid back into the bottle and slowly re-draw the liquid into syringe
  5. Holding the bottle upright, remove the syringe from the port and replace the small port cap
  6. Attach a microcapillary delivery tip to the syringe. The tip may be bent to improve access
  7. Place tip sub-gingivally and apply drop-wise to accessible mucous membrane to accessible mucous membrane (such as the buccal and lingual sulcus) by slowly depressing the syringe plunger
  8. Wait one minute for maximum anesthesia before beginning the procedure
7 steps of directions for use

Reasons to switch to Cetacaine

Clinical tips

  • For optimal use, apply Cetacaine on two to three teeth at a time. If necessary, reapply until pain is controlled without exceeding 0.4ml.
  • Using a microbrush is recommended when periodontal pocketing is not deep but the tissues are inflamed and sensitive. Place a few drops of Cetecaine in a Dappen Dish and apply with a microbrush by running it along the sulcus.


Should never be used for injection. Should not be administered to patients who are hypersensitive to any of its ingredients or known to have cholinesterase deficiencies. Should not be used under dentures or cotton rolls, as retention of the active ingredients could possibly cause an escharotic effect. The complete product monograph is available by contacting us at 1-888-442-7070 or here.

Featured Publications

A Topical Anesthetic for Periodontal Procedures

A Topical Anesthetic for Periodontal Procedures

Clinicians Report June 2009, Volume 2, Issue 6

Clinicians Report June 2009, Volume 2, Issue 6

Compounded Topical Anesthetics in Orthodontics

Compounded Topical Anesthetics in Orthodontics


Consult MSDS