What is...


Plant-based bioflavonoids


Plant based, patent protected, specific complex of bioflavonoids

Against 21 more commun strains of cold & flu

Antibacterial & antiviral properties


Bind with bacterial cell walls to effect extracellular and soluble proteins through hydrogen bonding which the bacteria and viruses need to survive.

Disrupt the microbial membranes including cell wall polypeptides and membrane-bound enzymes.

The bioflavonoids (hydroxylated phenols) have been shown to be toxic to microorganisms as they effect enzyme inhibition. The bioflavonoids have been found to stimulate macrophages which have an indirect negative effect on infections.


Bioflavonoids are naturally present in plants, fruit and vegetables, there are over 6000 identifed having a wide range of uses including anti-oxidants & food ingredients.
The key ingredients of Flavobac™ are extracted from immature bitter oranges through a specialised extraction & filtration process. The extracted biofavonoids are then combined with a number of fruit acids to produce the core biofavonoid complex, Flavobac™.
Recent interest in these substances has been stimulated by the potential health bene ts arising from the antioxidant activities of these polyphenolic compounds. As a dietary component, flavonoids are thought to have health-promoting properties due to their high antioxidant capacity both in vivo and in vitro systems. They have the ability to induce human protective enzyme systems. Flavonoids are located in the nucleus of mesophyll cells and within centers of ROS generation.


A British team of scientists has been working since the late 1990s to achieve a biotechnological breakthrough in pathogen control. Their rather optimistic hypothesis at that time was that if they could build on research initiated in the 1930s by Hungarian Nobel Prize winner Szent-Gyorgi on Natural Bioflavonoids. The objective was to use Nature’s own ‘weapons’ to fight disease in plants, animals and humans.

Flavobac™ was one of the compound born from this research from a former ICI chemist in the UK, Ian Ripley, the M.D., founder of Citrox Biosciences Ltd. Bioflavonoids are naturally present in plants, fruit and vegetables, there are over 6000 identified having a wide range of uses including anti-oxidants & food ingredients. Flavonoids consist of a large group of polyphenolic compounds having a benzo--pyrone structure and are ubiquitously present in plants. They are synthesized by phenylpropanoid pathway. Available reports tend to show that secondary metabolites of phenolic nature including flavonoids are responsible for the variety of pharmacological activities [13, 14]. Flavonoids are hydroxylated phenolic substances and are known to be synthesized by plants in response to microbial infection [15]. Their activities are structure dependent. The chemical nature of flavonoids depends on their structural class, degree of hydroxylation, other substitutions and conjugations, and degree of polymerization [16]. Recent interest in these substances has been stimulated by the potential health benefits arising from the antioxidant activities of these polyphenolic compounds. Functional hydroxyl groups in flavonoids mediate their antioxidant effects by scavenging free radicals and/or by chelating metal ions [17,18]. The chelation of metals could be crucial in the prevention of radical generation which damage target biomolecules. [19,20]

As a dietary component, flavonoids are thought to have health-promoting properties due to their high antioxidant capacity both in vivo and in vitro systems [21, 22]. Flavonoids have ability to induce human protective enzyme systems. The number of studies has suggested protective effects of flavonoids against many infectious (bacterial and viral diseases) and degenerative diseases such as cardiovascular diseases, cancers, and other age-related diseases [14, 20-22].The mechanisms involved in protection provided by flavonoids are described separately in this review. Flavonoids also act as a secondary antioxidant defense system in plant tissues exposed to different abiotic and biotic stresses. Flavonoids are located in the nucleus of mesophyll cells and within centers of ROS generation. They also regulate growth factors in plants such as auxin [23]. Biosynthetic genes have been assembled in several bacteria and fungi for enhanced production of flavonoids [24]. This review deals with the structural aspects of flavonoids and their protective roles against many human diseases. Functions of flavonoids in plants and their microbial production have also been described.

There has been an upsurge of interest in the therapeutic potential of medicinal plants which might be due to their phenolic compounds, specifically to flavonoids [25, 26]. Flavonoids have been consumed by humans since the advent of human life on earth, that is, for about 4 million years. They have extensive biological properties that promote human health and help reduce the risk of diseases.

The key ingredients of Flavobac are extracted from immature bitter oranges through a specialised extraction & filtration process. The extracted bioflavonoids are then combined with a number of fruit acids to produce the core bioflavonoid complex, Flavobac™.



  • HumanRhinovirus
  • InfluenzaA
  • HumanImmunodeficiencyVirus(HIV)
  • UrbaniSARS
  • Africanswinefever
  • Avianinfluenza
  • Foot&mouthdisease
  • Gumborovirus
  • Herpesvirustype1&type2
  • Herpeszoster
  • HepatitisA&B
  • NewcastleDisease
  • Sever Acute Respiratory Syndrome (SARS)
    Yeast and Fungi

  • Aspergillus flavus
  • Aspergillusniger
  • Aspergillusterreus
  • Botrytiscinerea
  • Candidaalbicans
  • Candidaglabrata
  • Chaetoniumglobosum
  • Cladosporium
  • Collectotricumsp.
  • Fusariumsp.
  • Mucorsp.
  • Penicilliumsp.
  • Penicilliumdigitatum
  • Penicilliumfuniculosum
  • Penicilliumitalicum
  • Penicilliumroqueforti
  • Phomopsisortl
  • Pullularia pullulans
  • Pythium sp.
  • Trichophyton interdigital
  • Trichophyton mentagrophytes

  • Histomonasmeleagradis
  • Giardialamblia
  • Entamoeabahistolytica
  • Blastocystishominis

  • Campylobacterjejuni Dipiodia natalensis
  • Escherichiacoli
  • Geotrichumcandidium
  • Klebsiellapneumonia
  • Lactobacilluspentoaceticus
  • Legionellapneumophila (NCTC 11192)
  • Listeriamonocytogenes
  • MRSA (clinical strain)
  • Mycobacteriumfortutium(NCTC8573)
  • Proteusvulgaris
  • Pseudomonasaeruginosa (ATCC 15442)
*All of the pathogens/viruses are tested at independent laboratories. Certificates and reports available on request.
Cold & Flu Guard bottle

An evidence-based, patients-convenient and highly effective solution for your vulnerable patients and the ones concerned with the contraction and transmission of the most commun strains of cold & flu

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  1. Lu, C.-W.; Liu, X.-F.; Jia, Z.-F. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet Lond. Engl. 2020, 395, e39.
  2. To, K.K.-W.; Tsang, O.T.-Y.; Chik-Yan Yip, C.; Chan, K.-H.; Wu, T.-C.; Chan, J.M.C.; Leung, W.-S.; Chik, T.S.-H.; Choi, C.Y.-C.; Kandamby, D.H.; et al. Consistent detection of 2019 novel coronavirus in saliva. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 2020. doi:org/10.1093/cid/ciaa149
  3. Peng, X.; Xu, X.; Li, Y.; Cheng, L.; Zhou, X.; Ren, B. T ransmission routes of 2019-nCoV and controls in dental practice. Int. J. Oral Sci. 2020, 12, 9.
  4. Zou, L.; Ruan, F.; Huang, M.; Liang, L.; Huang, H.; Hong, Z.; Yu, J.; Kang, M.; Song, Y.; Xia, J.; et al. SARSCoV- 2 Viral Load in Upper Respiratory Specimens of Infected Patients. N. Engl. J. Med. 2020, 382, 1177-1179.
  5. Sultan, A.S.; Kong, E.F.; Rizk, A.M.; Jabra-Rizk, M.A. The oral microbiome: A Lesson in coexistence. PLoS Pathog. 2018, 14, e1006719.
  6. Zaura, E.; Nicu, E.A.; Krom, B.P.; Keijser, B.J.F. Acquiring and maintaining a normal oral microbiome: current perspective. Front. Cell. Infect. Microbiol. 2014, 4, 85.
  7. Deo, P.N.; Deshmukh, R. Oral microbiome: Unveiling the fundamentals. J. Oral Maxillofac. Pathol. JOMFP 2019, 23, 122–128.
  8. Lim, Y.; Totsika, M.; Morrison, M.; Punyadeera, C. Oral Microbiome: A New Biomarker Reservoir for Oral and Oropharyngeal Cancers. Theranostics 2017, 7, 4313–4321.
  9. Lamarre, A.; Talbot, P.J. Effect of pH and temperature on the infectivity of human coronavirus 229E. Can. J. Microbiol. 1989, 35, 972–974.
  10. Geller, C.; Varbanov, M.; Duval, R.E. Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies. Viruses 2012, 4, 3044–3068.
  11. Tonoyan, L.; Vincent-Bugnas, S.; Olivieri, C.-V.; Doglio, A. New Viral Facets in Oral Diseases: The EBV Paradox. Int. J. Mol. Sci. 2019, 20, 5861.
  12. Giacaman, R.A.; Asrani, A.C.; Gebhard, K.H.; Dietrich, E.A.; Vacharaksa, A.; Ross, K.F.; Herzberg, M.C. Porphyromonas gingivalis induces CCR5-dependent transfer of infectious HIV-1 from oral keratinocytes to permissive cells. Retrovirology 2008, 5, 29.
  13. M. F. Mahomoodally, A. Gurib-Fakim, and A. H. Subratty, Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius. Pharmaceutical Biology, vol. 43, no. 3, pp. 237–242, 2005.
  14. A. K. Pandey, Anti-staphylococcal activity of a pan-tropical aggressive and obnoxious weed Pariheniumhisterophorus: an in vitro study. National Academy Science Letters, vol. 30, no. 11-12, pp. 383–386, 2007.
  15. R. A. Dixon, P. M. Dey, and C. J. Lamb, Phytoalexins: enzymology and molecular biology. Advances in Enzymology and Related Areas of Molecular Biology, vol. 55, pp. 1–136, 1983.
  16. E. H. Kelly, R. T. Anthony, and J. B.Dennis, Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. Journal of Nutritional Biochemistry, vol. 13, no. 10, pp. 572–584, 2002.
  17. S. Kumar, A. Mishra, and A. K. Pandey, Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models. BMC Complementary and Alternative Medicine, vol. 13, article 120, 2013.
  18. S. Kumar and A. K. Pandey, Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. Vegetos, vol. 26, pp. 301–307, 2013.
  19. M. Leopoldini, N. Russo, S. Chiodo, and M. Toscano, Iron chelation by the powerful antioxidant flavonoid quercetin. Journal of Agricultural and Food Chemistry, vol. 54, no. 17, pp. 6343–6351, 2006.
  20. S. Kumar, A. Gupta, and A. K. Pandey, Calotropis procera root extract has capability to combat free radical mediated damage. ISRN Pharmacology, vol. 2013,Article ID 691372, 8 pages, 2013.
  21. N. C. Cook and S. Samman, Review: flavonoids-chemistry, metabolism, cardioprotective effects and dietary sources. Journal of Nutritional Biochemistry, vol. 7, no. 2, pp. 66–76, 1996. 12 The ScientificWorld Journal
  22. C. A. Rice-Evans, N. J. Miller, P. G. Bolwell, P. M. Broamley, and J. B. Pridham, The relative antioxidant activities of plantderived polyphenolic flavonoids. Free Radical Research, vol. 22, no. 4, pp. 375–383, 1995.
  23. G. Agati, E. Azzarello, S. Pollastri, and M. Tattini, Flavonoids as antioxidants in plants: location and functional significance Plant Science, vol. 196, pp. 67–76, 2012.
  24. F.Du, F. Zhang, F. Chen et al., Advances inmicrobial heterologous production of flavonoids. African Journal of Microbiology Research, vol. 5, no. 18, pp. 2566–2574, 2011.
  25. F. Pourmorad, S. J.Hosseinimehr, and N. Shahabimajd, Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. The African Journal of Biotechnology, vol. 5, no. 11, pp. 1142–1145, 2006.
  26. S. Kumar and A. K. Pandey, Antioxidant, lipo-protective and antibacterial activities of phytoconstituents present in Solanum xanthocarpum root. International Review of Biophysical Chemistry, vol. 3, no. 3, pp. 42–47, 2012.
  27. Hooper, S.J., et al., Antimicrobial activity of Flavobac™ bioflavonoid preparations against oral microorganisms. 2011. 210(1): p. E22.
  28. Aqil, F., I. Ahmad, and Z.J.T.j.o.B. Mehmood, Antioxidant and free radical scavenging properties of twelve traditionally used Indian medicinal plants. 2006. 30(3): p. 177-183.
  29. Fernandes, M., et al., Antioxidant and antimicrobial activities of Psidium guajava L. spray dried extracts. 2014. 60: p. 39-44.
  30. Tait, S., et al., Antiviral activity of substituted homoisoflavonoids on enteroviruses. 2006. 72(3): p. 252-255.
  31. Sindt, C.W., et al., Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study. 2012. 6: p. 511.
  32. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7:79-89.
  33. Kavasi RM, Berdiaki A, Spyridaki I, Corsini E, Tsatsakis A, Tzanakakis G, Nikitovic D. HA metabolism in skin homeostasis and inflammatory disease. Food Chem Toxicol. 2017;101:128-138.
  34. Valachová K, Volpi N, Stern R, Soltes L. Hyaluronan in Medical Practice. Curr Med Chem. 2016;23:3607-3617.
  35. Müller F. Oral hygiene reduces the mortality from aspiration pneumonia in frail elders. J Dent Res. 2015;94:14S–16S.
  36. Paju S, Scannapieco FA. Oral biofilms, periodontitis, and pulmonary infections. Oral Dis. 2007;13:508–512.
  37. Linden GJ, Herzberg MC; Working group 4 of joint EFP/AAP workshop. Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40 Suppl 14:S20–S23.