Plant based, patent protected, specific complex of bioflavonoids
Against 21 more commun strains of cold & flu
Antibacterial & antiviral properties
MECHANISM OF ACTION
Bind with bacterial cell walls to effect extracellular and soluble proteins through hydrogen bonding which the bacteria and viruses need to survive.
Disrupt the microbial membranes including cell wall polypeptides and membrane-bound enzymes.
The bioflavonoids (hydroxylated phenols) have been shown to be toxic to microorganisms as they effect enzyme inhibition. The bioflavonoids have been found to stimulate macrophages which have an indirect negative effect on infections.
WHAT ARE BIOFLAVONOIDS?
Bioflavonoids are naturally present in plants, fruit and vegetables, there are over 6000 identifed having a wide range of uses including anti-oxidants & food ingredients.
The key ingredients of Flavobac™ are extracted from immature bitter oranges through a specialised extraction & filtration process. The extracted biofavonoids are then combined with a number of fruit acids to produce the core biofavonoid complex, Flavobac™.
Recent interest in these substances has been stimulated by the potential health bene ts arising from the antioxidant activities of these polyphenolic compounds. As a dietary component, flavonoids are thought to have health-promoting properties due to their high antioxidant capacity both in vivo and in vitro systems. They have the ability to induce human protective enzyme systems. Flavonoids are located in the nucleus of mesophyll cells and within centers of ROS generation.
HISTORY OF FLAVOBAC™
A British team of scientists has been working since the late 1990s to achieve a biotechnological breakthrough in pathogen control. Their rather optimistic hypothesis at that time was that if they could build on research initiated in the 1930s by Hungarian Nobel Prize winner Szent-Gyorgi on Natural Bioflavonoids. The objective was to use Nature’s own ‘weapons’ to fight disease in plants, animals and humans.
Flavobac™ was one of the compound born from this research from a former ICI chemist in the UK, Ian Ripley, the M.D., founder of Citrox Biosciences Ltd. Bioflavonoids are naturally present in plants, fruit and vegetables, there are over 6000 identified having a wide range of uses including anti-oxidants & food ingredients. Flavonoids consist of a large group of polyphenolic compounds having a benzo--pyrone structure and are ubiquitously present in plants. They are synthesized by phenylpropanoid pathway. Available reports tend to show that secondary metabolites of phenolic nature including flavonoids are responsible for the variety of pharmacological activities [13, 14]. Flavonoids are hydroxylated phenolic substances and are known to be synthesized by plants in response to microbial infection . Their activities are structure dependent. The chemical nature of flavonoids depends on their structural class, degree of hydroxylation, other substitutions and conjugations, and degree of polymerization . Recent interest in these substances has been stimulated by the potential health benefits arising from the antioxidant activities of these polyphenolic compounds. Functional hydroxyl groups in flavonoids mediate their antioxidant effects by scavenging free radicals and/or by chelating metal ions [17,18]. The chelation of metals could be crucial in the prevention of radical generation which damage target biomolecules. [19,20]
As a dietary component, flavonoids are thought to have health-promoting properties due to their high antioxidant capacity both in vivo and in vitro systems [21, 22]. Flavonoids have ability to induce human protective enzyme systems. The number of studies has suggested protective effects of flavonoids against many infectious (bacterial and viral diseases) and degenerative diseases such as cardiovascular diseases, cancers, and other age-related diseases [14, 20-22].The mechanisms involved in protection provided by flavonoids are described separately in this review. Flavonoids also act as a secondary antioxidant defense system in plant tissues exposed to different abiotic and biotic stresses. Flavonoids are located in the nucleus of mesophyll cells and within centers of ROS generation. They also regulate growth factors in plants such as auxin . Biosynthetic genes have been assembled in several bacteria and fungi for enhanced production of flavonoids . This review deals with the structural aspects of flavonoids and their protective roles against many human diseases. Functions of flavonoids in plants and their microbial production have also been described.
There has been an upsurge of interest in the therapeutic potential of medicinal plants which might be due to their phenolic compounds, specifically to flavonoids [25, 26]. Flavonoids have been consumed by humans since the advent of human life on earth, that is, for about 4 million years. They have extensive biological properties that promote human health and help reduce the risk of diseases.
The key ingredients of Flavobac are extracted from immature bitter oranges through a specialised extraction & filtration process. The extracted bioflavonoids are then combined with a number of fruit acids to produce the core bioflavonoid complex, Flavobac™.
FLAVOBAC HAS BEEN TESTED EFFECTIVELY AGAINST:
- Sever Acute Respiratory Syndrome (SARS)
Yeast and Fungi
- Aspergillus flavus
- Pullularia pullulans
- Pythium sp.
- Trichophyton interdigital
- Trichophyton mentagrophytes
- Campylobacterjejuni Dipiodia natalensis
- Legionellapneumophila (NCTC 11192)
- MRSA (clinical strain)
- Pseudomonasaeruginosa (ATCC 15442)
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